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A clinical research trial at the Personalized OncoGenomics Program is changing the way scientists think about the future of cancer care.
Six years ago Zuri Scrivens, the mother of a toddler, was very ill with incurable breast cancer that had spread to her liver and lymph nodes. Today Zuri has no signs of cancer, not because of a miraculous new cancer drug, but thanks to a diabetes medication.
CRACKING CANCER follows a group of patients with incurable cancer on a trailblazing journey through a highly experimental clinical trial at the BC Cancer Agency in Vancouver called POG -- Personalized OncoGenomics.
The trial compares patients' normal DNA -- each cell's complete set of instructions -- with that of their tumors, to find the genetic mutations causing their cancer. Zuri's cancer driver was a mutation that caused a very high growth factor. The team plowed through decades of data to isolate which drug in all of medicine, not just cancer, might block that growth factor. They zeroed in on a diabetes medication. Zuri received the drug and standard hormone treatment. Within 5 months, her cancer became undetectable.
POG offers a radical new way of treating cancer, not according to where it originates in the body, but rather as a disease of genetic mutations. Thousands more will join the trial, all hoping for their own salvation, all helping science to crack the cancer code.
By the time you hit midlife, odds are you or someone close to you will be touched by cancer. Cancer remains a potentially lethal lottery and everyone's experience is different. But appropriate exercise under professional supervision - before, during, or after treatment - seems to substantially improve your odds.
This promgram meets a group of cancer patients that is experiencing extraordinary benefits from prescribed targeted exercise programs.
By Bernadette Wegenstein, Elizabeth Karr, Rebecca Messner and Jon Reiss
THE GOOD BREAST explores breast cancer as ritual, presenting today's rise of the mastectomy in the U.S. as a modern form of breast sacrifice.
The no-nonsense veteran breast cancer surgeon Dr. Lauren Schnaper believes that fear and ignorance are fueling an alarming rate of medically unnecessary mastectomies in America. But for the four women allowing us intimate access to their mastectomies and their individual and most personal breast reconstructions, their search for the "good breast" is a necessity. We witness the ups and downs of the women's breast loss and reconstructions, from the collateral damage of infected implants and dying flaps to a cosmetic nipple exchange, and a miraculous Lat Dorsi breast reconstruction.
The film blends archival medical films and the history of the mastectomy since William S. Halsted with the surprising journey taken by Dr. Schnaper and her partner, the plastic surgeon Dr. Slezak, to Catania, Sicily, to experience the annual festival of the breast Saint Agatha, the third largest such celebration in the world. What the doctors learn about the Sicilian saint of the breast as an ancient symbol of female strength leads to a provocative connection between our contemporary American culture of the mastectomy and this ancient veneration of the breast.
The loss of the breast of each of our patient characters illustrates that the breast is far more than just an organ; but rather contains within it the history, suffering and power of female identity.
Should cancer really be understood and treated as a "disease of the genes" or could another avenue - which was once abandoned but has now been taken up again - enable us to understand and treat it?
Researchers and doctors in various countries think so, and want to revolutionize treatment. For them, cancer is a disorder of cellular metabolism, which could be treated with a few simple molecules. This film invites us to take stock of their research.
Explores the relationship between breast cancer and exposure to toxic chemicals.
Breast cancer receives a great deal of attention in the U.S. An entire month is devoted to it; millions of dollars are raised for it. People run, walk, write and conduct research -- all for the cause of breast cancer. Yet, despite these efforts, growing numbers of American women develop breast cancer each year and we still do not know why, or how best to prevent it. Most breast cancer funding and research has gone toward treatment, and finding the elusive cure. Far less emphasis has been given to prevention and discovering the causes of breast cancer.
TOXIC BUST, a thought-provoking and visually compelling documentary, uncovers the growing evidence which links breast cancer to chemical exposure.
The film follows a 40-something woman who finds a lump in her breast, but like the majority of women with breast cancer, she has none of the "established" risk factors. As she questions what may have caused her cancer, the film focuses on three cancer "hotspots" (Cape Cod MA, SF Bay Area, and hi-tech manufacturing workers) to more fully explore the connection between breast cancer and chemical exposure in the home, community and workplace.
TOXIC BUST also raises questions about the long term health costs associated with early childhood chemical exposure and highlights the disproportionate toxic burden carried by low-income communities and workers.
Interweaving fiction and documentary, hard science and personal testimony, TOXIC BUST challenges viewers to question how chemical use in the United States undermines the health of its citizens.
This type of skin cancer is usually not difficult to detect, and when found early, it is almost always curable, but left untreated too long, it becomes one of the most deadliest of all cancers. This program explains self-exams and sun exposure precautions that can lower the risk. Protection early in life can help prevent this cancer in adulthood. People who have experienced melanoma tell about their experiences with the illness, from discovery through treatment.
With Walter J. Curran, Jr., MD; David S. Ettinger, MD; Chandra P. Belani, MD; Dawn Moose, MD
Integration of Chemotherapy and Radiation for Non-Small Cell Lung Cancer; New Drugs in Treatment of NSCLC; Recent Improvements in the Management of NSCLC; Management of Anorexia and Cachexia for Patients w/ NSCLC.
William U. Shipley, MD(Moderator); Derek Raghavan, MD, PhD; Harry W. Herr, MD; Mark S. Soloway, MD; M'Liss A. Hudson, MD; Niall M. Heney, MD; Paul F. Schellhammer, MD; Donald S. Kaufman, MD
Topics include superficial and invisible bladder cancer, diagnosis of patients presenting with either hematuria and dysuria, endoscopic and intravesical chemotherapeutic methods, systematic chemotherapy for advanced bladder cancer.
Laszlo Tabar, MD; Linda Warren, MD; Richard Bird, MD; Jeffery Weinreb, MD; Kevin Fox, MD; Barbara Fowble, MD; Michael Osborne, MD; John Hainsworth, MD
Topics included in this program are: The effectiveness of mammographic screening; the diagnostic workup: mammography, sonography, MRI; and therapeutic options: radiotherapy, chemotherapy, and surgury.
Leta Truett, RN, MN, CCRN; Deborah M. Thorpe, PhD, RN, CS; Mary Cunningham, RN, MS; Talulah Ruger, RN, BSN
This program features physicians and doctors discussing various appropriate nursing rules and interventions in pain management. The major areas of discussion are as follows: acute or post-operative pain management - current techniques and therapies, barriers to effective management; chronic non-malignant pain management or behavioral/cognitive pain management- classifications of chronic non-malignant pain characteristics, data collection, and treatment, cancer pain management - dosing regimens; nursing assessment for acute, chronic non-malignant or cancer pain - current therapies and techniques, point controlled analgesia (PCA), epidural analgesia.
Richard Champlin, MD; Bruce D. Cheson, MD; Michael Bishop, MD; Frederick R. Appelbuam, MD; Frank J. Giles, MD; Charles A. Schiffer, MD
For physicians who have interest in or occasion to diagnose or treat cancer patients. Presentations will feature discussions about various leukemias and treatments of the disease.
Joseph Oesterling, MD; Arthur Porter, MD; Anthony Zeitman, MD; Jerry Ritchie, MD; David Paulson, MD; Michael K. Brawer, MD
Featured topics of this program include the use of PSA in diagnosis and staging of prostate cancer, transrectal ultrasound, improving the results of radical treatment for locally advanced prostate cancer, radical prostatectomy, maximum androgen deprivation therapy, and radionuclide therapy for metastatic prostate cancer.
Seth Lerner, MD; Ron Bukowski, MD; Chris Logothetis, MD; Richard Williams, MD; Michael Sorodsky, MD
This program deals with testes cancer; bladder cancer- BCG, alternatives to BCG therapy, and metastatic bladder cancer; and renal cell cancer - single agent therapies including IL-2 high dose and alpha interferon, combination therapy of IL-2 low dose and alpha interferon, and surgery to treat renal cell - does it improve survivability.
Seth Lerner, MD; Ron Bukowski, MD; Chris Logothetis, MD; Richard Williams, MD; Michael Sorodsky, MD
This program deals with testes cancer; bladder cancer- BCG, alternatives to BCG therapy, and metastatic bladder cancer; and renal cell cancer - single agent therapies including IL-2 high dose and alpha interferon, combination therapy of IL-2 low dose and alpha interferon, and surgery to treat renal cell - does it improve survivability
Paul Shelhamer, MD; Charles Metzger, MD; Anthony Zeitman, MD; Mark Solloway, MD
A prestigious panel of physicians discussing the management of prostate cancer with specific topics including: anti-androgens and the treatment of metastatic prostate cancer; management of prostate disease in a single specialty managed care environment; neoadjuvant therapy and radiotherapy.
Richard Payne, MD; Lillian M. Nail, PhD, RN, FAAN; Carol P. Curtis, RN, MSN, OCN; Faith Ottery, MD, PhD, FACN; Deborah M. Thorpe, PhD, RN, CS
Discuss pain initiative and its impact on our country; understand the challenges in managing cancer pain; describe principles of pain management; recognize fatigue as a side-effect of cancer treatment and understand nutritional oncology as an approach to cost/complication prevention.