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Cell and Molecular

CELL BIOLOGY: STRUCTURE, FUNCTION, AND PROCESSES - CELL DIVISION AND GROWTH

The cell cycle is a series of developmental and growth events that chart the normal life of a cell. This program uses easy-to-follow animation to illustrate the growth phases of the cell cycle and the processes of mitosis and cytokinesis that follow. The distinct phases of mitosis-including prophase, metaphase, anaphase and telophase-are described in detail. The program also explains meiosis, a variation of mitosis involving the formation of gametes in two stages. Apoptosis, or programmed cell death, is also covered, including the effects of uncontrolled cell division (cancer).

DVD / 2014 / 22 minutes

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CELL BIOLOGY: STRUCTURE, FUNCTION, AND PROCESSES - CELL METABOLISM AND RESPIRATION

All living organisms need energy to perform day-to-day tasks. Using straightforward, vibrant animation to anchor otherwise complex ideas, this program shows how that energy is created through the metabolic processes of catabolism, aerobic cellular respiration, and anabolism. Respiration is covered in depth, with detailed explanations of glycolysis, the Krebs cycle and the electron transport chain. Also covered is fermentation and anaerobic cellular respiration, and how cells help build large, complex molecules through the process of anabolism.

DVD / 2014 / 22 minutes

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CELL BIOLOGY: STRUCTURE, FUNCTION, AND PROCESSES - CELL STRUCTURE AND FUNCTION

This program explores the basic structure of both animal and plant cells and the specific functions that different cell components serve. After an overview of a complete cell, individual segments dive in to detail each of the specific parts. Discrete, pedagogical segments cover: the plasma membrane, extracellular matrix, flagellum and cilia, the nucleus, nucleolus, nuclear envelope, cytosol and cytoplasm, the rough and smooth endoplasmic reticula, the golgi apparatus, ribosomes, lysosomes, vacuoles, peroxisome, and mitochondria. Where plant and animal cells different is made clear, and separate segments on structures unique to plants include the cell wall, plasmodesmata, and chloroplasts.

DVD / 2014 / 22 minutes

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CELL BIOLOGY: STRUCTURE, FUNCTION, AND PROCESSES - STEM CELLS AND CELLULAR DIFFERENTIATION

That a tiny collection of cells can divide, multiply, and transform into the proper combination of lung cells, brain cells, bone, muscle, and more-eventually becoming a fully formed human being-is often referred to as the miracle of life. But at the cellular level, this is the story of stem cells, cellular differentiation, and gene expression. This program explores these topics, detailing the different types of stem cells (embryonic and adult), and when they leave the cell cycle to enter differentiation. Cell mutation, gene expression, and the process of epigenetics are also covered. Stem cell potency is also reviewed, as is the role and promise of stem cells in medical research, including the pros and cons of using embryonic versus adult-derived stem cells.

DVD / 2014 / 21 minutes

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IMMORTALISTS, THE

By David Alvarado & Jason Sussberg

Could the age-old quest for eternal life be realized in the next few decades? If so, is it even desirable?

The Immortalists follows two biomedical scientists seeking to radically extend human longevity through regenerative medicine. But not without controversy and concern.

Bill Andrews is a molecular biologist and famed long-distance runner now racing against the ultimate clock. "Hundreds of years from now, we're going to look back and be shocked by this horrible world we used to live in where people get old and die," says Andrews. Aubrey de Grey is one of the most famous figures in anti-aging research, a theoretical biologist. He believes the first person who could live to be 1,000 is alive today.

Andrews and de Grey differ in style and approach, but are united in their common crusade: to cure aging or die trying. De Grey proposes an intervention that would delete the telomerase gene in the body. Andrew's research is fundamentally the opposite - he is trying to trigger the gene in cells to produce telomerase.

They both publicly disagree with other biologists who believe that curing aging is neither possible nor desirable. In an Oxford debate, de Grey spars with British neurobiologist Colin Blakemore over the basic scientific and ethical questions.

As Andrews and de Grey battle their own aging and suffer the loss of loved ones, their journeys toward life without end ultimately become personal.

The Immortalists raises fundamental questions beyond whether eternal life is possible. How would being 'forever young' alter the human condition and our world?

DVD (Region 1, Closed Captioned) / 2014 / (Grades 10-Adult) / 52 minutes

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TEACHING SYSTEMS BIOLOGY MODULE 1: MOLECULES AND CELLS

Topics include: The Chemistry of Life, Cells, Inside the Eukaryotic Cell, and Cellular Energetics.

DVD / 2010 / 30 minutes

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TEACHING SYSTEMS BIOLOGY MODULE 3: MOLECULAR GENETICS

Topics include: History of DNA Research, DNA Code, the Central Dogma, DNA Technologies, Gene Regulation, and DNA Mutations.

DVD / 2010 / 30 minutes

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CELL, THE: CHEMISTRY OF LIFE

In Chemistry of Life, Dr Adam Rutherford explores how scientists began to probe ever more deeper into the cell in order to unlock the secret of life.

Chemistry Of Life picks up the story in T3bingen, Germany, where an unlikely experiment in 1869 provided the first clue. Using pus-covered bandages from injured Prussian War soldiers and the contents of a pig's stomach, Friedrich Miescher, a keen young scientist at Europe's first biochemistry lab, made a crucial discovery about the nucleus of all cells.

He found a strange molecule never seen in nature before. Since it was only found in the nucleus, he called it "nuclein"; we now know it as DNA. However, Miescher's discovery lay unnoticed for decades because nobody knew what the cell nucleus was for or why it was important.

But by turn of the 20th Century, scientists were beginning to observe cells in greater detail. Discovery after discovery began to reveal an unimaginably complex and exquisitely organised world within the cell. The nucleus was shown to contain chromosomes, the chromosomes to carry genes and the genes to contain essential information. That information was shown to be carried by one particular molecule, the molecule discovered by Miescher in 1869: DNA. So the "magic ingredient" at the heart of the cell - at the heart of life itself, had been discovered. Now scientists wanted to know how the DNA molecule could control every kind of living cell on Earth.

Adam travels to Switzerland to meet Walter Gehring, one of the pioneering scientists of the 20th Century. Together, they recreate some of the most bizarre and surprising experiments in all biology, first conducted by Gehring and his colleagues in the Eighties and Nineties. Back then, mutant flies with legs growing from their heads and eyes in random parts of their bodies helped show exactly how DNA controls the cell. They also demonstrated that the story of the cell is the story of the evolution of life itself. The cell has provided evidence that all life on Earth is related by a common ancestry.

Note: This BBC production not available in Hong Kong, Macau, Taiwan, Mainland China, Japan, USA, Canada.

DVD / 2009 / 50 minutes

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CELL, THE: HIDDEN KINGDOM

Hidden Kingdom explores the story of the discovery that all life on Earth is made of cells. It was a shocking revelation that overturned centuries of scientific and religious dogma. However, it began not with a scientist but with a Dutch linen merchant, Antoni van Leeuwenhoek.

Adam travels to van Leeuwenhoek's home town of Delft to discover how he revealed a hidden kingdom invisible to the naked eye, teeming with bizarre creatures he called "animalcules". It would be another two centuries before science revealed that these cells were the building blocks of every life form on the planet, from plankton to people.

Adam travels to the major centres of European science to trace the stories of the geniuses who got it wrong and laymen who got it right; of rivalries and secrecy; and of the sudden insights at dinner parties that would become the bedrock of modern biology.

Note: This BBC production not available in Hong Kong, Macau, Taiwan, Mainland China, Japan, USA, Canada.

DVD / 2009 / 50 minutes

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CELL, THE: THE SPARK OF LIFE

In The Spark of Life, Dr Adam Rutherford concludes his compelling journey through 350 years of science to discover the secrets of the cell - and of life itself.

The Spark Of Life begins with some of the earliest evidence of life on Earth: fossilised cells that are a staggering one billion years old. It is now believed that all life on Earth began with one primordial cell from which every living thing evolved. Today, however, knowledge of the cell has brought humankind to the brink of something truly profound. Scientists may be about to create living cells from scratch and, if they succeed, it will be the first life form on Earth that has not evolved from that original cell. It would be the Second Genesis. To show how this has become possible, Adam traces the scientific quest to understand how the first cells came into existence in Earth's distant past.

From bizarre experiments that recreated the toxic chemical soup of the early Earth, to startling new revelations from inside meteorites, he tracks down evidence of the very first living cells on the planet. At Harvard University, Adam meets the scientists at the Origin Of Life initiative who are coming close to creating living cells in the laboratory.

Filmed for the first time are Professor Jack Szostak's "proto-cells", which can feed, grow and divide in primitive ways - fulfilling some of the key requirements of life. Even more astonishing are Professor George Church's synthetic cell parts, which can perform the single most important process at the heart of all life: reading DNA code and carrying out its instructions.

Scientists using Church's techniques have already manipulated naturally occurring cells to do extraordinary things. Adam meets a team in San Francisco, led by Dr Steve del Caldayre, that has radically re-engineered bacteria cells so that, when fed sugar, they produce clean diesel oil. This new science of synthetic biology is already coming up with life-changing solutions to some of the most pressing challenges facing humankind.

But Adam asks how much further scientists will go when they cross the threshold and create new cells from scratch.

Note: This BBC production not available in Hong Kong, Macau, Taiwan, Mainland China, Japan, USA, Canada.

DVD / 2009 / 50 minutes

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BIOLOGY: THE FABRIC OF LIFE - CELLS AND THEIR STRUCTURES

Cells and their Structures covers the following topics:

the relationship between surface area and volume

types of microscopes

magnification vs. resolving power

characteristics of prokaryotic cells and their structures

characteristics of eukaryotic cells and their structures

contrasting plant and animal cells

cell fractionation

cellular organization in nature from cells to organism

a summary of cell theory

DVD / 2008 / (Grades 9-12, College, Adult) / 30 minutes

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CELL MEMBRANES: THE BOUNDARIES OF LIFE

Cell Membranes DVD begins by examining cell wall structure and the major functions of cellular membranes before introducing the fluid mosaic model of the phospholipid bilayer, and transport, recognition, and receptor proteins. The concepts of simple and facilitated diffusion, passive and active transport, and osmosis are illustrated. Endocytosis and exocytosis, the role of contractile and central vacuoles, and how desmosomes and tight junctions tie cells together and how plasmodesmata and gap junctions facilitate communication are explained.

DVD / 2006 / 31 minutes

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CELLULAR REPRODUCTION: MITOSIS, CYTOKINESIS, AND THE CELL CYCLE

Mitosis Video starts by introducing the cell cycle and briefly describing the process of binary fusion in prokaryotic cells before going on to a detailed look at the eukaryotic cell cycle from the G1, S and G2 phases of interphase through the prophase, metaphase, anaphase and telophase phases of mitosis. The difference between cytokinesis in animal and plant cells is then illustrated. The program concludes by explaining why an understanding of cellular division is critical to: conquering cancer, cloning organs, and perhaps even reversing aging.

DVD / 2006 / 30 minutes

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GLYCOLYSIS AND CELLULAR RESPIRATION: THE BIOLOGY OF ENERGY

Glycolysis and Cellular Respiration DVD looks first at the processes of glycolysis and fermentation the program then looks in detail at cellular respiration beginning with the structure of mitochondria. Following the entry of pyruvic acid into the mitochondrial matrix and the formation of acetyl CoA the program continues with an in-depth examination of the citric acid cycle. An exploration of the endosymbiotic hypothesis which offers an explanation of how photosynthesis and cellular respiration arose in eukaryotic cells concludes the program.

DVD / 2006 / 27 minutes

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MEIOSIS, SEXUAL REPRODUCTION, AND GENETIC VARIABILITY

Meiosis DVD begins by comparing asexual and sexual reproduction and describing chromosomes and homologous pairs. The difference between haploid and diploid cells and the three major eukaryotic life cycles are then described. The program goes on to a detailed description of all the stages of Meiosis I and II including prophase I and II, metaphase I and II, anaphase I and II, and telophase I and II. In the process students are introduced to phenomena such as crossing over and provided an explanation of how meiosis creates genetic variability in a species.

DVD / 2006 / 22 minutes

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STEM CELLS

Take your students inside James Thomson's laboratory at the University of Wisconsin where stem cells were first cultured to learn why this breakthrough is so important in the 21st century. This new video will help you show your students what stem cells are, how they are cultured, why they offer such potential for the future of our health and welfare. The program addresses both the science and the ethical dilemmas that accompany this advance in biology. Includes interviews with pioneers in stem cell technology and in stem cell ethics.

DVD (Closed Captioned) / 2005 / (Secondary, College) / 34 minutes

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DNA AND RNA: DECIPHERING THE CODE OF LIFE

By examining DNA and RNA in a historical framework, students gain understanding of the experiments that let to the Watson-Crick double helix model. The program describes the roles of DNA and RNA in protein synthesis and details how DNA transmits hereditary information. It also explains the DNA code and discusses the causes of such diseases as sickle-cell anemia.

DVD / 39 minutes

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CELLS: THE STRUCTURE OF LIFE

This program explains the difference between prokaryotic and eukaryotic cells and then explores in detail the structure and function of the major organelles found in eukaryotic cells. Examined organelles include: the nucleus, ribosomes, smooth and rough endoplasmic reticulum, the Golgi complex, lysosomes, chloroplasts, mitochondria, plastids, contractile and central vacuoles, cilia, flagella and the microtubules, microfilaments, and intermediate filaments that make up the cytoskeleton. The program concludes by looking at how cellular shape varies with cellular function.

DVD / 32 minutes

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MOLECULAR CLONING OF DNA

This DVD contains detailed illustrations which covers most of techniques used in DNA cloning. Live footage of most common technique is also shown in enough details.

Volume 1:

Introduction

Restriction & Modifying Enzymes

Bacteriophage Infection

Genomic Library

Plasmid Preparation

Gel Electrophoresis

DNA Subcloning

DNA Hybridization

Volume 2 :

Southern Blot & its applications

Dot Blot

DNA Sequencing

DNA Mutations

PCR (Polymerase Chain Reaction)

DNA Footprinting

Nuclease S1 Protection Assay

Polyacrylamide Gel Electrophoresis

Western Blot

DVD / 93 minutes

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